Alterations of plasma and cerebrospinal fluid glutamate levels in rats treated with the N-methyl-D-aspartate receptor antagonist, ketamine.

@article{Tomiya2006AlterationsOP,
  title={Alterations of plasma and cerebrospinal fluid glutamate levels in rats treated with the N-methyl-D-aspartate receptor antagonist, ketamine.},
  author={Masayuki Tomiya and Takeshi Fukushima and Junko Kawai and Chiaki Aoyama and Shigenobu Mitsuhashi and Tomofumi Santa and Kazuhiro Imai and Toshimasa Toyo'oka},
  journal={Biomedical chromatography : BMC},
  year={2006},
  volume={20 6-7},
  pages={
          628-33
        }
}
It has been reported that the repeated administration of a sub-anesthetic dose of an N-methyl-D-aspartate receptor antagonist, ketamine, can produce an animal model of schizophrenia. Since no information is available on the alterations of the amino acid levels in ketamine-treated rats, we investigated the amino acid composition in the plasma and cerebrospinal fluid of rats that were repeatedly administered with ketamine for 5 consecutive days (30 mg/kg/day). The plasma and cerebrospinal fluid… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS