Alterations of p53 gene in primary gastric cancer tissues.

@article{Hong1994AlterationsOP,
  title={Alterations of p53 gene in primary gastric cancer tissues.},
  author={Seongkwan Hong and Won Sik Hong and Ja June Jang and David S Lee and Nam Soo Cho and Marianna Eunsun Jung and Hyong Bai Kim and Gun Woo Ha and Inkwan Park and Dae Shik Cho},
  journal={Anticancer research},
  year={1994},
  volume={14 3B},
  pages={
          1251-5
        }
}
This study was conducted to investigate the p53 gene alterations in 25 surgically-resected gastric adenocarcinomas in the Korea Cancer Center Hospital by polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP) for exons 4-8 and immunohistochemical staining (IHCS) with anti-p53 antibody, DO-7. p53 mutations were detected in nine (36%) out of 25 cancer tissues by PCR-SSCP in exon 4-8: 0,1,1,6 and 1 mutations in exons 4,5,6,7 and 8, respectively. All tissues were also… CONTINUE READING

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