Alterations of myocardial dynamic stiffness implicating abnormal crossbridge function in human mitral regurgitation heart failure.

@article{Mulieri2002AlterationsOM,
  title={Alterations of myocardial dynamic stiffness implicating abnormal crossbridge function in human mitral regurgitation heart failure.},
  author={Louis A. Mulieri and W Barnes and Bruce Jason Leavitt and Frank P. Ittleman and Martin Lewinter and Norman R. Alpert and David W. Maughan},
  journal={Circulation research},
  year={2002},
  volume={90 1},
  pages={66-72}
}
Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The mechanism of FTI increase was investigated using sinusoidal length perturbation analysis to compare crossbridge function in skinned left ventricular (LV) epicardial muscle strips from 5 MR and 5 nonfailing (NF) control hearts. Myocardial dynamic stiffness was modeled as 3 parallel viscoelastic processes. Two processes characterize… CONTINUE READING

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