Alterations of mitochondrial enzymes contribute to cardiac hypertrophy before hypertension development in spontaneously hypertensive rats.

@article{Meng2009AlterationsOM,
  title={Alterations of mitochondrial enzymes contribute to cardiac hypertrophy before hypertension development in spontaneously hypertensive rats.},
  author={Chao Meng and Xian Jin and Li Xia and Shao-Ming Shen and Xiaoling Wang and Jun Cai and Guo-Qiang Chen and Li-shun Wang and Ning-yuan Fang},
  journal={Journal of proteome research},
  year={2009},
  volume={8 5},
  pages={2463-75}
}
Mitochondrial dysfunction is recently thought to be tightly associated with the development of cardiac hypertrophy as well as hypertension. However, the detailed molecular events in mitochondria at early stages of hypertrophic pathogenesis are still unclear. Applying two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) combined with MALDI-TOF/TOF tandem mass spectrometry, here we identified the changed mitochondrial proteins of left ventricular mitochondria in prehypertensive… CONTINUE READING

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