Alterations of hypothalamic catecholamines in the newborn offspring of gestational diabetic mother rats.

@article{Plagemann1998AlterationsOH,
  title={Alterations of hypothalamic catecholamines in the newborn offspring of gestational diabetic mother rats.},
  author={Andreas Plagemann and Thomas Harder and Ralf Lindner and K. W. Melchior and Alyssa Rake and F Rittel and Wolfgang Rohde and G{\"u}nter D{\"o}rner},
  journal={Brain research. Developmental brain research},
  year={1998},
  volume={109 2},
  pages={201-9}
}
Catecholamines are essential organizers of the developing brain. Throughout life, they are involved, e.g., in the regulation of body weight and metabolism by specific hypothalamic nuclei, which are suggested to be highly vulnerable to maternal gestational hyperglycemia. By application of streptozotocin (30 mg/kg, i.p.) gestational diabetes (GD) was induced in female rats. On the 1st day of life, male GD offspring were underweight (P<0.05) and hyperglycemic (P<0.05), while on the 21st day of… CONTINUE READING
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