Alterations of guanine nucleotide-binding proteins in post-mortem human brain in alcoholics.

@article{Ozawa1993AlterationsOG,
  title={Alterations of guanine nucleotide-binding proteins in post-mortem human brain in alcoholics.},
  author={Hiroki Ozawa and Y Katamura and Shinichi Hatta and Toshikazu Saito and Toshiaki Katada and Wieland Gsell and Lutz Fr{\"o}lich and Naohiko Takahata and Peter Franz Riederer},
  journal={Brain research},
  year={1993},
  volume={620 1},
  pages={174-9}
}
Qualitative and quantitative alterations of G proteins in membrane preparations from parietal and temporal cortex regions in post-mortem brains obtained from alcoholics and controls matched with respect to age and post-mortem delay were investigated by Western-blotting with polyclonal antibodies against specific G protein subunits and functional photoaffinity GTP binding. Quantitative immunoblotting showed that only Gs alpha (52 kDa species) in temporal cortex was significantly decreased (30… CONTINUE READING

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