Alterations of expression and regulation of transforming growth factor β in human cancer prostate cell lines

@article{Blanchere2002AlterationsOE,
  title={Alterations of expression and regulation of transforming growth factor $\beta$ in human cancer prostate cell lines},
  author={M. Blanchere and E. Saunier and C. Mestayer and M. Broshuis and I. Mowszowicz},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2002},
  volume={82},
  pages={297-304}
}
TGF beta can promote and/or suppress prostate tumor growth through multiple and opposing actions. Alterations of its expression, secretion, regulation or of the sensitivity of target cells can lead to a favorable environment for tumor development. To gain a better insight in TGF beta function during cancer progression, we have used different cultured human prostate cells: preneoplastic PNT2 cells, the androgen-dependent LNCaP and the androgen-independent PC3 and DU145 prostate cancer cell lines… Expand
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