Alterations of endothelium and smooth muscle function in monocrotaline-induced pulmonary hypertensive arteries.

@article{Ito2000AlterationsOE,
  title={Alterations of endothelium and smooth muscle function in monocrotaline-induced pulmonary hypertensive arteries.},
  author={Katsuaki Ito and Mariko Sato and Kazuo Ushijima and Masaaki Nakai and Kunihiksa Ito},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 4},
  pages={H1786-95}
}
We examined how monocrotaline (MCT), which impairs the endothelium and causes pulmonary hypertension, altered the endothelial regulation of pulmonary artery functions. Rats were given a single injection of MCT (60 mg/kg sc). Pulmonary arteries were depolarized to -48.3 +/- 2.6 and -39.8 +/- 2.2 mV at 2 and 3 wk after treatment with MCT, respectively (control arteries -59.9 +/- 1.9 mV). The basal tone in the resting state was only slightly elevated at 3 wk in endothelium-intact arteries. Removal… CONTINUE READING

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