Alterations of cyclo-oxygenase products and NO in responses to angiotensin II of resistance arteries from the spontaneously hypertensive rat.

@article{Crtes1996AlterationsOC,
  title={Alterations of cyclo-oxygenase products and NO in responses to angiotensin II of resistance arteries from the spontaneously hypertensive rat.},
  author={Steyner F C{\^o}rtes and Ramaroson Andriantsitohaina and J. C. Stoclet},
  journal={British journal of pharmacology},
  year={1996},
  volume={119 8},
  pages={1635-41}
}
1. The involvement of cyclo-oxygenase (COX) products and nitric oxide (NO) in contractile responses of resistance arteries to angiotensin II (AII) were investigated in small mesenteric arteries from spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats. 2. In endothelium intact vessels, AII induced concentration-dependent responses without any significant difference between the two strains. However, removal of functional endothelium resulted in enhanced sensitivity to AII, the pD2… CONTINUE READING
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