Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors.

@article{BallesterosYaez2010AlterationsOC,
  title={Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors.},
  author={Inmaculada Ballesteros-Ya{\~n}ez and Ruth Benavides-Piccione and Jean-Pierre Bourgeois and Jean-Pierre Changeux and Javier DeFelipe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 25},
  pages={11567-72}
}
The neuronal nicotinic acetylcholine receptors (nAChRs) are allosteric membrane proteins involved in multiple cognitive processes, including attention, learning, and memory. The most abundant form of heterooligomeric nAChRs in the brain contains the beta2- and alpha4- subunits and binds nicotinic agonists with high affinity. In the present study, we investigated in the mouse the consequences of the deletion of one of the nAChR components: the beta2-subunit (beta2(-/-)) on the microanatomy of… CONTINUE READING

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