Alterations of circulating follicular helper T cells and interleukin 21 in diffuse large B-cell lymphoma

@article{Cha2014AlterationsOC,
  title={Alterations of circulating follicular helper T cells and interleukin 21 in diffuse large B-cell lymphoma},
  author={Zhanshan Cha and Huijun Guo and Xiaohua Tu and Yan Zang and Haihui Gu and Haihan Song and Baohua Qian},
  journal={Tumor Biology},
  year={2014},
  volume={35},
  pages={7541-7546}
}
CD4+ CXCR5+ T cell in peripheral blood is known as circulating follicular helper T cell (Tfh), which can produce interleukin 21 (IL-21). In the current study, we investigated changes of circulating Tfh and its correlation with IL-21 in diffuse large B-cell lymphoma (DLBCL). Circulating Tfh and its subtypes were detected by flow cytometry in the peripheral blood of 32 healthy donors and 62 DLBCL cases. Data demonstrated that percentage of circulating Tfh in CD4+ T cells was significantly… CONTINUE READING

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