Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies.

@article{Schechter1990AlterationsOC,
  title={Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies.},
  author={Lee E. Schechter and F J Bola{\~n}os and Henri Gozlan and Laurence Lanfumey and Samir Haj-Dahmane and A. M. Laporte and C. M. Fattaccini and Michel Hamon},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={255 3},
  pages={1335-47}
}
Inasmuch as sustained treatment with the 5-hydroxytryptamine1A (5-HT1A) agonist, ipsapirone, is necessary for inducing anxiolytic and antidepressant effects in the clinic, investigations were performed for assessing the possible changes in serotoninergic and dopaminergic neurotransmission in the brain of rats 24 hr after a 2-week treatment with this drug. Receptor binding assays with membranes and quantiative autoradiography indicated that the twice-daily administration of ipsapirone (5 mg/kg i… CONTINUE READING

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