Alterations of blood vessel development by endothelial cells overexpressing fibroblast growth factor-2.

  title={Alterations of blood vessel development by endothelial cells overexpressing fibroblast growth factor-2.},
  author={Domenico Ribatti and Anna Gualandris and Mirella Belleri and Luisa Massardi and B Nico and Marco Rusnati and Patrizia Dell'era and Angelo Vacca and Luisa Roncali and Marco Presta},
  journal={The Journal of pathology},
  volume={189 4},
A close relationship exists between angiogenesis and the formation of vascular lesions. The development of the vascular system in the chick embryo chorioallantoic membrane (CAM) may thus represent a model to study the effects of the deregulation of endothelial cell behaviour. Alterations of the developing vascular tree of the CAM were observed after exposure to murine aortic endothelial (MAE) cells overexpressing human fibroblast growth factor-2 (FGF2) cDNA (pZipFGF2 MAE cells), or to their… CONTINUE READING


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Interaction of high molecular weight basic fibroblast growth factor (bFGF) with Fig. 6—Gel filtration and heparin-Sepharose affinity chromatography of pZipFGF2 MAE cell CM

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