Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil.

@article{AbiDargham1998AlterationsOB,
  title={Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil.},
  author={Anissa Abi-Dargham and John H. Krystal and Satish Anjilvel and Barbara Ellen Scanley and Sami S. Zoghbi and Ronald M. Baldwin and Nallakkandi Rajeevan and Steve Ellis and Ismene L Petrakis and John P. Seibyl and Dennis S. Charney and Marc Laruelle and Robert B. Innis},
  journal={The American journal of psychiatry},
  year={1998},
  volume={155 11},
  pages={1550-5}
}
OBJECTIVE Alterations in cortical benzodiazepine receptor density have been described in postmortem and in vivo studies of alcoholic subjects. The authors attempted to replicate these findings using single photon emission computed tomography and the benzodiazepine receptor radiotracer [123I]iomazenil. METHOD They measured the distribution volume of benzodiazepine receptors in 11 recently detoxified patients with type II alcoholism and 11 healthy comparison subjects. The tracer was given as a… CONTINUE READING
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