Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging.

@article{Tian1998AlterationsOA,
  title={Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging.},
  author={Ligeng Tian and Quan Cai and Hao Wei},
  journal={Free radical biology & medicine},
  year={1998},
  volume={24 9},
  pages={1477-84}
}
Oxygen free radicals have been hypothesized to play an important role in the aging process. To investigate the correlation between the oxidative stress and aging, we have determined the levels of oxidative protein damage and lipid peroxidation in the brain and liver, and activities of antioxidant enzymes in the brain, liver, heart, kidney, and serum from the Fisher 344 rats at ages of 1, 6, 12, 18, and 24 months. The results showed that the level of oxidative protein damage (measured as… CONTINUE READING
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