Alterations of angiotensin II receptor contents in hypertrophied hearts.

  title={Alterations of angiotensin II receptor contents in hypertrophied hearts.},
  author={Nobuharu Fujii and Makoto Tanaka and Junji Ohnishi and Kazunori Yukawa and Eriko Takimoto and Satoshi Shimada and Masae Naruse and Fumihiro Sugiyama and Ken-ichi Yagami and Kiriko Murakami},
  journal={Biochemical and biophysical research communications},
  volume={212 2},
Tsukuba hypertensive mice, which carry the human genes for renin and angiotensinogen, show cardiac hypertrophy as well as hypertension due to activation of the renin-angiotensin system (RAS). Here, we compared the cardiac angiotensin II (Ang II) receptor contents in these and normotensive control mice by means of ligand binding studies and competitive reverse transcription-polymerase chain reaction analyses. The content of the Ang II receptor type 1 (AT1) was significantly higher at both the… CONTINUE READING