Alterations of anaphase-promoting complex genes in human colon cancer cells

@article{Wang2003AlterationsOA,
  title={Alterations of anaphase-promoting complex genes in human colon cancer cells},
  author={Qing Wang and Caroline Moyret-Lalle and Florence Couzon and Christine Surbiguet-Clippe and J. -Ch. Saurin and Thierry Lorca and Claudine Navarro and Alain Puisieux},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={1486-1490}
}
Ubiquitin-mediated proteolysis of cell cycle regulators is a major element of the cell cycle control. The anaphase-promoting complex (APC/C) is a large multisubunit ubiquitin-protein ligase required for the ubiquitination and degradation of G1 and mitotic checkpoint regulators. APC/C-dependent proteolysis regulates cyclin levels in G1, and triggers the separation of sister chromatids at the metaphase–anaphase transition and the destruction of mitotic cyclins at the end of mitosis. Furthermore… CONTINUE READING
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