Alterations of amino acids and glutamate transport in the DBA/2J mouse retina; possible clues to degeneration

@article{Schuettauf2006AlterationsOA,
  title={Alterations of amino acids and glutamate transport in the DBA/2J mouse retina; possible clues to degeneration},
  author={Frank Schuettauf and Sebastian Thaler and Sylvia Bolz and J C De Fries and Hubert Kalbacher and Anna Mańkowska and David Zurakowski and Eberhart Zrenner and Robert Rejdak},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2006},
  volume={245},
  pages={1157-1168}
}
The DBA/2J mouse spontaneously develops ocular hypertension and time-dependent progressive retinal ganglion cell (RGC) loss. This study examines changes in amino acid levels in the vitreous, and changes in the expression of retinal glutamate transporters and receptors that occur during the progression of this pathology. Retinas were obtained from DBA/2J mice at ages 3, 6 and 11 months. C57BL/6 mice were used as age-matched controls. Vitreal amino acid content was measured with HPLC. Western… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice.

Investigative ophthalmology & visual science • 1998
View 6 Excerpts
Highly Influenced

The glutamate transporter GLT1 C is expressed by retinal ganglion cells in both glaucoma and AMD

DV Pow, LT Macnab, E WoldeMussie, Sullivan RKP
Invest Ophthalmol Vis Sci • 2006

Similar Papers

Loading similar papers…