Alterations of adenosine A1 receptors in morphine dependence.

@article{Kaplan1994AlterationsOA,
  title={Alterations of adenosine A1 receptors in morphine dependence.},
  author={Gary B. Kaplan and Kimberly A. Leite-Morris and M. T. Sears},
  journal={Brain research},
  year={1994},
  volume={657 1-2},
  pages={347-50}
}
The possibility that central adenosine A1 and A2a receptors mediate opiate dependence was examined in morphine-treated mice using radioligand binding methods. Mice treated with morphine for 72 h demonstrated significant increases in naloxone precipitated abstinence behaviors of jumping, wet-dog shakes, teeth chattering, forepaw trends, forepaw tremors and diarrhea compared to vehicle-treated mice. Increased concentrations of cortical adenosine A1 receptor sites, but not striatal adenosine A2a… CONTINUE READING
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…