Alterations of adenomatous polyposis Coli (APC) gene in oral squamous cell carcinoma.

@article{Chang2000AlterationsOA,
  title={Alterations of adenomatous polyposis Coli (APC) gene in oral squamous cell carcinoma.},
  author={Kuo-Wei Chang and Shu Chun Lin and Kathy A. Mangold and Michon Jean and Tzu Chiang Yuan and Shih-Chang Lin and Chew Shun Chang},
  journal={International journal of oral and maxillofacial surgery},
  year={2000},
  volume={29 3},
  pages={223-6}
}
The present study assessed the roles of Adenomatous Polyposis Coli (APC) tumor suppressor gene during oral carcinogenesis. Reduction of APC transcript levels and APC loss of heterozygosity (LOH) were found in 39% (7/18) and 29% (10/34) cases of oral squamous cell carcinoma (OSCC), respectively. The apparent APC heterozygosity (27%) in non-cancerous matched oral tissue (NCMOT) adjacent to OSCC at an exon 11 locus was significantly lower than normally found in the Taiwanese population (49… CONTINUE READING

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The present study assessed the roles of Adenomatous Polyposis Coli ( APC ) tumor suppressor gene during oral carcinogenesis .
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