Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption.

@article{BenbrahimTallaa2008AlterationsOS,
  title={Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption.},
  author={L. Benbrahim-Tallaa and B. Siddeek and A. Bozec and V. Tronchon and A. Florin and Claire Friry and E. Tabone and C. Mauduit and M. Benahmed},
  journal={The Journal of endocrinology},
  year={2008},
  volume={196 1},
  pages={
          21-31
        }
}
Fetal androgen disruption, induced by the administration of anti-androgen flutamide (0.4, 2, and 10 mg/kg day) causes a long-term apoptosis in testicular germ cells in adult male rat offspring. One of the questions raised by this observation is the role of the Sertoli cells in the adult germ cell apoptotic process. It is shown here that Sertoli cells originating from 15-day-old rats treated in utero with the anti-androgen (10 mg/kg d) did no longer protect adult germ cells against apoptosis… Expand
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