Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications

@article{Ghosh2008AlterationsOR,
  title={Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications},
  author={Susmita Ghosh and Amlan Kanti Ghosh and Guru Prasad Maiti and Neyaz Alam and Anup Roy and Susanta Roychoudhury and Chinmay Kumar Panda},
  journal={Human Genetics},
  year={2008},
  volume={125},
  pages={189-198}
}
Deletion of chromosomal 3p12.3 was suggested to be associated with dysplastic lesions of head and neck. This region harbors two candidate tumor suppressors ROBO1/DUTT1, ROBO2 and two non-coding RNAs (ncRNAs) located at intron 2 of ROBO1/DUTT1. Aim of this study is to understand the role of these genes in development of head and neck squamous cell carcinoma. A collection of 72 dysplastic lesions and 116 HNSCC samples and two oral cancer cell lines were analyzed for ROBO1/DUTT1 and ROBO2 deletion… CONTINUE READING

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