Alterations of INK4a p16—p14ARF /INK4b p15 Expression and Telomerase Activation in Meningioma Progression

@article{Simon2001AlterationsOI,
  title={Alterations of INK4a p16—p14ARF /INK4b p15 Expression and Telomerase Activation in Meningioma Progression},
  author={Matthias Simon and T Park and Gertraud K{\"o}ster and Ralph Mahlberg and Matthias Hackenbroch and Jan Patrick Bostr{\"o}m and Thomas Loening and Johannes Schramm},
  journal={Journal of Neuro-Oncology},
  year={2001},
  volume={55},
  pages={149-158}
}
Dysregulation of cell cycle progression and telomerase activation have been implicated in malignant tumor progression as well as in the evasion of senescence and immortalization. We have investigated expression of the cell cycle control and tumor suppressor genes INK4a p16–p14ARF, INK4b p15–p10 and RB, and their relation to telomerase activation during malignant meningioma progression. 7/26 (27%) benign, 3/12 (25%) atypical but 4/7 (57%) anaplastic tumors lacked both, p16 and p15 protein… CONTINUE READING
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