Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications

@inproceedings{Silverman2016AlterationsOE,
  title={Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications},
  author={Brittany R. Silverman and Jiaqi Shi},
  booktitle={International journal of molecular sciences},
  year={2016}
}
Pancreatic cancer is one of the most aggressive human cancer types with a five-year survival less than 7%. Emerging evidence revealed that many genetic alterations in pancreatic cancer target epigenetic regulators. Some of these mutations are driver mutations in cancer development. Several most important mechanisms of epigenetic regulations include DNA methylation, histone modifications (methylation, acetylation, and ubiquitination), chromatin remodeling, and non-coding ribonucleic acids (RNAs… CONTINUE READING
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