Alterations of Choroidal Blood Flow Regulation in Young Healthy Subjects with Complement Factor H Polymorphism

@inproceedings{Told2013AlterationsOC,
  title={Alterations of Choroidal Blood Flow Regulation in Young Healthy Subjects with Complement Factor H Polymorphism},
  author={Reinhard Told and Stefan Palkovits and Helmuth Haslacher and Sophie Frantal and Doreen Schmidl and Agnes Boltz and Michael Lasta and Semira Kaya and Ren{\'e} M Werkmeister and Gerhard Garh{\"o}fer and Leopold F. Schmetterer},
  booktitle={PloS one},
  year={2013}
}
A common polymorphism in the complement factor H gene (rs1061170, Y402H) is associated with a high risk of age-related macular degeneration (AMD). In the present study we hypothesized that healthy young subjects homozygous for the high-risk haplotype (CC) show abnormal choroidal blood flow (ChBF) regulation decades before potentially developing the disease. A total of 100 healthy young subjects were included in the present study, of which 4 subjects were excluded due to problems with genotyping… CONTINUE READING

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