Alterations of BDNF and trkB mRNA Expression in the 6-Hydroxydopamine-Induced Model of Preclinical Stages of Parkinson’s Disease: An Influence of Chronic Pramipexole in Rats

Abstract

Our recent study has indicated that a moderate lesion of the mesostriatal and mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease, induces a depressive-like behaviour which is reversed by chronic treatment with pramipexole. The purpose of the present study was to examine the role of brain derived neurotrophic factor (BDNF… (More)
DOI: 10.1371/journal.pone.0117698

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@inproceedings{BerghauzenMaciejewska2015AlterationsOB, title={Alterations of BDNF and trkB mRNA Expression in the 6-Hydroxydopamine-Induced Model of Preclinical Stages of Parkinson’s Disease: An Influence of Chronic Pramipexole in Rats}, author={Klemencja Berghauzen-Maciejewska and Jadwiga Wardas and Barbara Kosmowska and Urszula Głowacka and Katarzyna Kuter and Krystyna Ossowska}, booktitle={PloS one}, year={2015} }