Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis

  title={Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis},
  author={Leo Jeng and Alexandra V Yamshchikov and Suzanne E. Judd and Henry M Blumberg and Greg S Martin and Thomas R. Ziegler and Vin Tangpricha},
  journal={Journal of Translational Medicine},
  pages={28 - 28}
Vitamin D insufficiency is common in hospitalized patients. Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial peptide produced by macrophages and neutrophils. Thus, the relationship between vitamin D status and LL-37 production may be of importance for host immunity, but little data is available on this subject, especially in the setting of human sepsis syndrome and other critical illness. Plasma… CONTINUE READING


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