Alterations in vasoactive intestinal polypeptide-related peptides after pentylenetetrazole-induced seizures in rat brain.

@article{Romualdi1992AlterationsIV,
  title={Alterations in vasoactive intestinal polypeptide-related peptides after pentylenetetrazole-induced seizures in rat brain.},
  author={Patrizia Romualdi and Giovanni M Lesa and Andrea Donatini and Gianfranco Balboni and Roberto Tomatis and Simona Ferri},
  journal={European journal of pharmacology},
  year={1992},
  volume={229 2-3},
  pages={149-53}
}
The possible involvement of vasoactive intestinal polypeptide-related peptides in pentylenetetrazol (PTZ)-induced seizures in rats was investigated. The chemoconvulsant PTZ was administered (45 mg/kg i.p.) either acutely or chronically for three days. The detailed time course of changes in VIP-(1-28) and VIP-(22-28) was examined in several rat brain areas 5 and 20 min and 24 h after acute treatment and after three days chronic treatment. Ir-VIP levels dramatically decreased in all areas 5 min… CONTINUE READING

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Glycine-extended processing intermediate of proVIP: a new form of VIP in the rat.

Biochemical and biophysical research communications • 1991
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