Alterations in tumour suppressor gene p53 in human gliomas from Indian patients

@article{Phatak2002AlterationsIT,
  title={Alterations in tumour suppressor gene p53 in human gliomas from Indian patients},
  author={Pornima Phatak and Senthil Kalai Selvi and T Satheesh Divya and Alangar Sathyaranjandas Hegde and Sridevi Hegde and Kumaravel Somasundaram},
  journal={Journal of Biosciences},
  year={2002},
  volume={27},
  pages={673-678}
}
Alterations in the tumour suppressorp53 gene are among the most common defects seen in a variety of human cancers. In order to study the significance of thep53 gene in the genesis and development of human glioma from Indian patients, we checked 44 untreated primary gliomas for mutations in exons 5–9 of thep53 gene by PCR-SSCP and DNA sequencing. Sequencing analysis revealed six missense mutations. The incidence of p53 mutations was 13⋅6% (6 of 44). All the six mutations were found to be located… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 40 references

A pilot study of recurrence of human glial tumours in light of p 53 heterozygosity status

  • D JamesC, E Carlbom, J Dumanski, M Hansen, P CollinsV, K CaveneeW
  • J . Biosci
  • 1999

A pilot study of recurrence of human glial tumours in light of p53 heterozygosity

  • K CJain, P Chattopadhyay, C Sarkar, S Sinha, A KMahapatra
  • status; J. Biosci
  • 1999

The alternative product from the human CDKN 2 A locus , p 14 ARF , participates in a regulatory feedback loop with p 53 and MDM 2

  • A vonDeimling, R Eibl, +6 authors O Wiestler
  • 1998

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