Alterations in transcription factor binding at the IL-2 promoter region in anergized human CD4+ T lymphocytes.


BACKGROUND The mechanisms responsible for the induction of clonal anergy are not well understood. We have utilized an in vitro model of human T cell anergy to explore the perturbations in cell signaling at the level of interleukin (IL)-2 gene transcription and to define the contribution of other cytokines to this effect. METHODS An in vitro model of… (More)


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