Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons.

@article{Harasawa2016AlterationsIT,
  title={Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons.},
  author={Ichiro Harasawa and Joshua P Johansen and Howard L Fields and F rank Porreca and Ian D. Meng},
  journal={Pain},
  year={2016},
  volume={157 1},
  pages={166-73}
}
The rostral ventromedial medulla (RVM) exerts both inhibitory and excitatory controls over nociceptive neurons in the spinal cord and medullary dorsal horn. Selective ablation of mu-opioid receptor (MOR)-expressing neurons in the RVM using saporin conjugated to the MOR agonist dermorphin-saporin (derm-sap) attenuates stress and injury-induced behavioral hypersensitivity, yet the effect of RVM derm-sap on the functional integrity of the descending inhibitory system and the properties of RVM… CONTINUE READING
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