Alterations in the regulation of lipolysis in brown and white adipose tissue in the diabetic state.

@article{Saggerson1989AlterationsIT,
  title={Alterations in the regulation of lipolysis in brown and white adipose tissue in the diabetic state.},
  author={E. David Saggerson},
  journal={Biochemical Society transactions},
  year={1989},
  volume={17 1},
  pages={
          47-9
        }
}
  • E. Saggerson
  • Published 1 February 1989
  • Biology
  • Biochemical Society transactions
Triacylglycerol mobilization is a central feature in the metabolism of both brown and white adipose tissues. It is generally accepted that the rate-limiting enzyme, the hormone-sensitive lipase, is activated by cyclic-AMP-stimulated protein phosphorylation [ 11. Hence the regulation by hormones of cyclic AMP synthesis and disposal is important in this system. White adipocytes possess B-adrenoceptors together with receptors for corticotropin and glucagon through which G,-coupled activation of… 

Effects of diet on lipolysis and its regulation

Hormone-sensitive lipase, and hence lipolysis, is thus acutely stimulated by a variety of hormones and the neurohumoral transmitter, noradrenaline, and the activity of this enzyme is enhanced by phosphorylation by cyclic-AMP-dependent kinase (A-kinase).

Effects of diet on lipolysis and its regulation

  • R. Vernon
  • Biology
    Proceedings of the Nutrition Society
  • 1992
Hormone-sensitive lipase, and hence lipolysis, is thus acutely stimulated by a variety of hormones and the neurohumoral transmitter, noradrenaline, and the activity of this enzyme is enhanced by phosphorylation by cyclic-AMP-dependent kinase (A-kinase).