Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis.

@article{Alexopoulos2003AlterationsIT,
  title={Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis.},
  author={Leonidas G. Alexopoulos and Mansoor A. Haider and Thomas Parker Vail and Farshid Guilak},
  journal={Journal of biomechanical engineering},
  year={2003},
  volume={125 3},
  pages={
          323-33
        }
}
In articular cartilage, chondrocytes are surrounded by a pericellular matrix (PCM), which together with the chondrocyte have been termed the "chondron." While the precise function of the PCM is not know there has been considerable speculation that it plays a role in regulating the biomechanical environment of the chondrocyte. In this study, we measured the Young's modulus of the PCM from normal and osteoarthritic cartilage using the micropipette aspiration technique, coupled with a newly… CONTINUE READING

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