Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics.

@article{Wand1991AlterationsIT,
  title={Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics.},
  author={Gary Wand and Adrian Dobs},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1991},
  volume={72 6},
  pages={1290-5}
}
The impact of chronic alcohol abuse on the hypothalamic-pituitary-adrenal (HPA) axis was investigated in actively drinking, nondepressed alcoholics with no evidence of liver disease. Fourteen male alcoholics and 13 matched nonalcoholics were studied. Although alcoholics and controls had similar decrements in cortisol levels after metyrapone blockade, plasma ACTH and 11-deoxycortisol levels in alcoholics were 60% (P less than 0.05) and 40% (P less than 0.05), respectively, of control values. To… CONTINUE READING