Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids

@inproceedings{JimnezLpez2010AlterationsIT,
  title={Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids},
  author={Jos{\'e} M. Jim{\'e}nez-L{\'o}pez and Pablo R{\'i}os-Marco and Carmen Marco and Josefa L. Segovia and Maria Paz Carrasco},
  booktitle={Lipids in Health and Disease},
  year={2010}
}
The alkylphospholipid analog miltefosine (hexadecylphosphocholine) is a membrane-directed antitumoral and antileishmanial drug belonging to the alkylphosphocholines, a group of synthetic antiproliferative agents that are promising candidates in anticancer therapy. A variety of mechanisms have been suggested to explain the actions of these compounds, which can induce apoptosis and/or cell growth arrest. In this review, we focus on recent advances in our understanding of the actions of… CONTINUE READING