Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids

@article{JimnezLpez2010AlterationsIT,
  title={Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids},
  author={J. Jim{\'e}nez-L{\'o}pez and Pablo R{\'i}os-Marco and C. Marco and J. Segovia and M. P. Carrasco},
  journal={Lipids in Health and Disease},
  year={2010},
  volume={9},
  pages={33 - 33}
}
The alkylphospholipid analog miltefosine (hexadecylphosphocholine) is a membrane-directed antitumoral and antileishmanial drug belonging to the alkylphosphocholines, a group of synthetic antiproliferative agents that are promising candidates in anticancer therapy. A variety of mechanisms have been suggested to explain the actions of these compounds, which can induce apoptosis and/or cell growth arrest. In this review, we focus on recent advances in our understanding of the actions of… Expand
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