Alterations in the histaminergic system in the substantia nigra and striatum of Parkinson's patients: a postmortem study

@article{Shan2012AlterationsIT,
  title={Alterations in the histaminergic system in the substantia nigra and striatum of Parkinson's patients: a postmortem study},
  author={Ling Shan and Koen A M Bossers and Sabina Luchetti and Rawien Balesar and Dick F. Swaab},
  journal={Neurobiology of Aging},
  year={2012},
  volume={33},
  pages={1488.e1-1488.e13}
}
Earlier studies showed neuronal histamine production in the hypothalamic tuberomamillary nucleus to be unchanged in Parkinson's disease (PD), whereas the histamine levels and innervation in the substantia nigra (SN) increased. In the present study we used quantitative polymerase chain reaction (qPCR) to assess the changes in the histaminergic system in the SN, caudate nucleus (CN), and putamen (PU) in 7 PD patients and 7 controls. The messenger RNA (mRNA) expression of the histamine receptor-3… CONTINUE READING
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