Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT₁A, GABA(A), and NMDA receptors.

@article{You2012AlterationsIT,
  title={Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT₁A, GABA(A), and NMDA receptors.},
  author={In-Jee You and Yang-Hee Jung and Min-Jung Kim and Seung-Hwan Kwon and Sa-Ik Hong and Seok-Yong Lee and Choon-gon Jang},
  journal={Neuropharmacology},
  year={2012},
  volume={62 2},
  pages={1034-43}
}
The transient receptor potential vanilloid type 1 channel (TRPV1) receptors are expressed in various regions of the brain. Much less is known about whether TRPV1 receptors affect higher brain functions. In the present study, we demonstrated that TRPV1-knockout (TRPV1KO) mice showed antidepressant-like behaviors in a novelty-suppressed feeding test and forced swim test when compared to wild-type (WT) mice. Additionally, TRPV1KO mice exhibited increased aggressiveness and reduced social… CONTINUE READING
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