Alterations in the bone marrow microenvironment may elicit defective hematopoiesis: a comparison of aplastic anemia, chronic myeloid leukemia, and normal bone marrow.

@article{Park2017AlterationsIT,
  title={Alterations in the bone marrow microenvironment may elicit defective hematopoiesis: a comparison of aplastic anemia, chronic myeloid leukemia, and normal bone marrow.},
  author={Meerim Park and Chan-Jeoung Park and Young Wook Cho and Seongsoo Jang and Jung-Hee Lee and Je-Hwan Lee and K. Lee and Young Ho Lee},
  journal={Experimental hematology},
  year={2017},
  volume={45},
  pages={
          56-63
        }
}
Hematopoiesis involves complex interactions between hematopoietic cells and the bone marrow (BM) microenvironment. The specific causes and mechanisms underlying dysregulated hematopoiesis are unknown. Here, BM biopsy specimens from patients with aplastic anemia (AA) and chronic myeloid leukemia (CML) and normal marrow were analyzed by semiquantitative immunohistochemistry to determine changes in the hematopoietic stem cell (HSC) compartment and BM microenvironment. HSC levels were lowest in AA… CONTINUE READING

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