Alterations in the balance of protein kinase and phosphatase activities and age-related impairments of synaptic transmission and long-term potentiation.

@article{Hsu2002AlterationsIT,
  title={Alterations in the balance of protein kinase and phosphatase activities and age-related impairments of synaptic transmission and long-term potentiation.},
  author={Kuei-Sen Hsu and C C Huang and Y Liang and H Wu and Y Chen and Shiow-Win Lo and Wen-Chia Ho},
  journal={Hippocampus},
  year={2002},
  volume={12 6},
  pages={787-802}
}
Aging is associated with an impaired ability to maintain long-term potentiation (LTP), but the underlying cause of the impairment remains unclear. To gain a better understanding of the cellular and molecular mechanisms responsible for this impairment, the synaptic transmission and plasticity were studied in the CA1 region of hippocampal slices from adult (6-8 months) and poor-memory (PM)-aged (23-24 months) rats. The one-way inhibitory avoidance learning task was used as the behavioral paradigm… CONTINUE READING