Alterations in temporal/spatial distribution of GFAP- and vimentin-positive astrocytes after spinal cord contusion with the New York University spinal cord injury device.

@article{Baldwin1998AlterationsIT,
  title={Alterations in temporal/spatial distribution of GFAP- and vimentin-positive astrocytes after spinal cord contusion with the New York University spinal cord injury device.},
  author={Shawn A Baldwin and Ryan Broderick and Deborah A Blades and Stephen William Scheff},
  journal={Journal of neurotrauma},
  year={1998},
  volume={15 12},
  pages={1015-26}
}
Astrocytes become reactive as a result of various types of lesions and upregulate 2 intermediate filaments, glial fibrillary acidic protein (GFAP), and the developmentally regulated protein vimentin. Young female Sprague-Dawley rats were subjected to a spinal cord contusion at segment T10 using the New York University injury device. Animals were killed at 1, 2, 7, 14, and 30 days postinjury. Horizontal spinal cord sections spanning segments T7-T13 were assessed with antibodies to both… CONTINUE READING
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