• Biology, Medicine
  • Published in
    The Journal of comparative…
    2018
  • DOI:10.1002/cne.24530

Alterations in synaptic density and myelination in response to exposure to high-energy charged particles.

@article{Dickstein2018AlterationsIS,
  title={Alterations in synaptic density and myelination in response to exposure to high-energy charged particles.},
  author={Dara L. Dickstein and Ronan Talty and Erin R. Bresnahan and Merina Varghese and Bayley Perry and William G M Janssen and Allison Sowa and Erich Giedzinski and Lauren Apodaca and Janet E. Baulch and Munjal M. Acharya and Vipan K. Parihar and Charles L. Limoli},
  journal={The Journal of comparative neurology},
  year={2018},
  volume={526 17},
  pages={
          2845-2855
        }
}
High-energy charged particles are considered particularly hazardous components of the space radiation environment. Such particles include fully ionized energetic nuclei of helium, silicon, and oxygen, among others. Exposure to charged particles causes reactive oxygen species production, which has been shown to result in neuronal dysfunction and myelin degeneration. Here we demonstrate that mice exposed to high-energy charged particles exhibited alterations in dendritic spine density in the… CONTINUE READING

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Alterations in synaptic density and myelination in response to exposure to high-energy charged particles

DL Dickstein, R Talty, E Bresnahan
  • J Comp Neurol. 2018;526:2845–2855
  • 2018