Alterations in steroid hormone production by porcine ovarian granulosa cells caused by bisphenol A and bisphenol A dimethacrylate

@article{Mlynarcikova2005AlterationsIS,
  title={Alterations in steroid hormone production by porcine ovarian granulosa cells caused by bisphenol A and bisphenol A dimethacrylate},
  author={Alzbeta Bujnakova Mlynarcikova and Jaroslav Kolena and M{\'a}ria Fickov{\'a} and Soňa Scsukov{\'a}},
  journal={Molecular and Cellular Endocrinology},
  year={2005},
  volume={244},
  pages={57-62}
}
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90 Citations

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Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells
Simultaneous effects of endocrine disruptor bisphenol A and flavonoid fisetin on progesterone production by granulosa cells.
Bisphenol A attenuates thyroxine-induced apoptosis in ovarian granulosa cells of pigs.
TLDR
It was demonstrated that T4 affected 17β-estradiol accumulation and induced cellular apoptosis, but did not affect granulosa cell proliferation, while BPA attenuates T4-induced apoptosis by regulating 17β, oestrogen receptor-mediated signalling pathways.
Bisphenol S Impaired Human Granulosa Cell Steroidogenesis in Vitro
TLDR
Environmental levels of BPS (nanomolar range) did not induce changes in steroidogenesis in human granulosa cells, and acute effects might be similar to chronic effects of physiological BPS levels.
Bisphenol analogs AF, S and F: effects on functional characteristics of porcine granulosa cells.
The impact of bisphenol S on bovine granulosa and theca cells
TLDR
This study suggests for the first time that BPS may alter oestradiol production by bovine granulosa cells, albeit at a concentration that is unlikely to be physiologically relevant.
Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway.
TLDR
Data show that BPA targets the estradiol biosynthesis pathway in the ovary, and pregnenolone was unable to protect follicles from BPA induced inhibition of steroidogenic enzymes compared with the DMSO control.
Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles.
Bisphenol A concentration-dependently increases human granulosa-lutein cell matrix metalloproteinase-9 (MMP-9) enzyme output.
Bisphenol A and S impaired ovine granulosa cell steroidogenesis.
TLDR
BPS does not appear to be a safe alternative for BPA regarding GC functions, and further investigations are required to elucidate BPA and BPS mechanisms of action.
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References

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TLDR
Exposure of humans to bisphenol A (BPA), a monomer in polycarbonate plastics and a constituent of resins used in food packaging and dentistry, is significant and further studies are warranted to assess the effects of BPA on male fertility.
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TLDR
These environmental chemicals appear to inhibit cAMP formation and steroidogenesis in mLTC-1 Leydig tumor cells by preventing the coupling between LH receptor and the adenylate cyclase.
The xenoestrogen bisphenol A induces growth, differentiation, and c-fos gene expression in the female reproductive tract.
TLDR
The studies demonstrate that the molecular and morphological alterations induced by BPA in the uterus and vagina are nearly identical to those induced by estradiol; the vagina appears to be especially sensitive to the estrogenic actions of BPA.
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TLDR
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TLDR
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TLDR
Results indicates that BPA exerts its effects in ER subtype specific way, thus suggesting that the mode of action of endocrine disruptors are more complex than thought.
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TLDR
It is concluded that due to exchange of steroid metabolites between the cocultured cell types, the final steroid products are different by far from the expected contributions of each individually cultured cell type.
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TLDR
These results are consistent with those of Dodds and Lawson who found that BPA induces persistent vaginal cornification in ovariectomized rats exposed to three twice-daily injections of 85 mg/kg BPA, but they conflict with the reported inactivity of BPA in the immature mouse uterotrophic assay.
Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure.
TLDR
Accumulation of BPA in early fetuses and significant exposure during the prenatal period are suggested, which must be considered in evaluating the potential for human exposure to endocrine-disrupting chemicals.
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