Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility.

Abstract

OBJECTIVE To evaluate the associations between proper protamine incorporation and DNA methylation at imprinted loci. DESIGN Experimental research study. SETTING Research laboratory. PATIENT(S) Three populations were tested-abnormal protamine patients, oligozoospermic patients, and fertile donors. INTERVENTION(S) The CpG methylation patterns were… (More)
DOI: 10.1016/j.fertnstert.2009.09.010

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