Alterations in spatial memory and anxiety in the MAM E17 rat model of hippocampal pathology in schizophrenia

  title={Alterations in spatial memory and anxiety in the MAM E17 rat model of hippocampal pathology in schizophrenia},
  author={François Gastambide and Amy M. Taylor and Clare Palmer and Heta Svard and Maija Karjalainen and Sanna K. Janhunen and Mark D. Tricklebank and D. M. Bannerman},
Adult rats exposed to methylazoxymethanol acetate (MAM) at embryonic day 17 (E17) display robust pathological alterations in the hippocampus. However, discrepancies exist in the literature regarding the behavioural effects of this pre-natal manipulation. Therefore, a systematic assessment of MAM E17-induced behavioural alterations was conducted using a battery of dorsal and ventral hippocampus-dependent tests. Compared to saline controls, MAM E17-treated rats displayed deficits in spatial… CONTINUE READING
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