Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling.

@article{Colleran2000AlterationsIS,
  title={Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling.},
  author={Patrick N Colleran and Michael Wilkerson and Susan A Bloomfield and Larry J. Suva and Russell T. Turner and Michael Delp},
  journal={Journal of applied physiology},
  year={2000},
  volume={89 3},
  pages={1046-54}
}
Bone loss occurs as a consequence of exposure to microgravity. Using the hindlimb-unloaded rat to model spaceflight, this study had as its purpose to determine whether skeletal unloading and cephalic fluid shifts alter bone blood flow. We hypothesized that perfusion would be diminished in the hindlimb bones and increased in skeletal structures of the forelimbs and head. Using radiolabeled microspheres, we measured skeletal perfusion during control standing and after 10 min, 7 days, and 28 days… CONTINUE READING
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