Alterations in serum immunoglobulin G subclasses in patients with ulcerative colitis and Crohn's disease.

@article{Macdermott1989AlterationsIS,
  title={Alterations in serum immunoglobulin G subclasses in patients with ulcerative colitis and Crohn's disease.},
  author={Richard P Macdermott and Goeffrey S. Nash and I. O. Auer and R D Shlien and Blair S. Lewis and Joseph V Madassery and Moon H. Nahm},
  journal={Gastroenterology},
  year={1989},
  volume={96 3},
  pages={764-8}
}
We have examined the concentration of immunoglobulin G (IgG) subclass antibodies in the sera of 27 patients with ulcerative colitis and 21 patients with Crohn's disease as well as in 11 normal controls and 11 patients with systemic lupus erythematosus. In comparison with a control mean serum IgG1 concentration of 5173 micrograms/ml, patients with ulcerative colitis exhibited a significantly increased mean serum concentration of 7924 micrograms/ml (p less than 0.05), whereas patients with Crohn… CONTINUE READING
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