Alterations in polyamine catabolic enzymes in human breast cancer tissue.

  title={Alterations in polyamine catabolic enzymes in human breast cancer tissue.},
  author={Heather M. Wallace and J. J. R. Duthie and D M Evans and S Lamond and kathleen. nicoll and Steven D. Heys},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={6 9},
High concentrations of acetyl polyamines have been observed in human breast cancer compared with the equivalent normal tissue, however, no explanation as to the reason for the increases has been proposed. In this study, we show that changes in the enzymes responsible for the breakdown of acetyl polyamines occur in breast cancer tissue. Spermidine/spermine N1-acetyltransferase, the first and rate-limiting enzyme in polyamine catabolism, is increased in the tumor tissue whereas polyamine oxidase… CONTINUE READING
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Polyamine metabolism in mammalian cells: excretion and acetylation

  • H. M. Wallace
  • Med. Sci. Res.,
  • 1987
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