Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.

@article{Rogan1995AlterationsIP,
  title={Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.},
  author={Eileen M. Rogan and Tracy M Bryan and Bharati Hukku and Kenneth Maclean and Andy C-M Chang and Elsa L Moy and Anna Englezou and S G Warneford and Luciano Dalla-Pozza and Roger R Reddel},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 9},
  pages={4745-53}
}
Normal cells have a strictly limited growth potential and senesce after a defined number of population doublings (PDs). In contrast, tumor cells often exhibit an apparently unlimited proliferative potential and are termed immortalized. Although spontaneous immortalization of normal human cells in vitro is an extremely rare event, we observed this in fibroblasts from an affected member of a Li-Fraumeni syndrome kindred. The fibroblasts were heterozygous for a p53 mutation and underwent… CONTINUE READING

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