Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene.

@article{Koh2011AlterationsIN,
  title={Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene.},
  author={Cheryl Koh and Bora Gurel and Siobhan Sutcliffe and Martin J. Aryee and Denise Schultz and Tsuyoshi Iwata and Motohide Uemura and Karen I. Zeller and Uzoma A Anele and Qizhi Zheng and Jessica L. Hicks and William Andrew Nelson and Chi V. Dang and Srinivasan Thomas Yegnasubramanian and Angelo M De Marzo},
  journal={The American journal of pathology},
  year={2011},
  volume={178 4},
  pages={1824-34}
}
Increased nucleolar size and number are hallmark features of many cancers. In prostate cancer, nucleolar enlargement and increased numbers are some of the earliest morphological changes associated with development of premalignant prostate intraepithelial neoplasia (PIN) lesions and invasive adenocarcinomas. However, the molecular mechanisms that induce nucleolar alterations in PIN and prostate cancer remain largely unknown. We verify that activation of the MYC oncogene, which is overexpressed… CONTINUE READING

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